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Philip Kestell Selected Research

vadimezan

6/2009Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.
3/2006Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.
8/2005Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Increased tumor vascular permeability.
4/2005Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells.
9/2004Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies.
5/2004Modulation of thalidomide pharmacokinetics by cyclophosphamide or 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice: the role of tumour necrosis factor.
3/2004Induction of tumour necrosis factor and interferon-gamma in cultured murine splenocytes by the antivascular agent DMXAA and its metabolites.
12/2003Improvement of the antitumor activity of intraperitoneally and orally administered 5,6-dimethylxanthenone-4-acetic acid by optimal scheduling.
6/2003Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.
1/2003Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.
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Philip Kestell Research Topics

Disease

22Neoplasms (Cancer)
11/2011 - 01/2002
6Necrosis
03/2006 - 01/2002
4Adenocarcinoma
07/2012 - 01/2002
3Multiple Myeloma
09/2004 - 05/2004
1Vascular System Injuries
06/2009
1Prolactinoma (Prolactinomas)
03/2006
1Tremor (Tremors)
08/2002
1Cognitive Dysfunction
08/2002
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2002
1Cachexia
01/2002
1Prostatic Neoplasms (Prostate Cancer)
01/2002

Drug/Important Bio-Agent (IBA)

17vadimezanIBA
06/2009 - 01/2002
12Pharmaceutical PreparationsIBA
04/2005 - 01/2002
5Thalidomide (Thalomid)FDA Link
09/2004 - 01/2002
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2004 - 01/2002
2N- (2- (dimethylamino)ethyl)- 2,6- dimethyl- 1- oxo- 1,2- dihydroxybenzo(b)- 1,6- naphthyridine- 4- carboxamideIBA
07/2012 - 11/2008
2AcidsIBA
03/2006 - 08/2005
2Serotonin (5 Hydroxytryptamine)IBA
08/2005 - 08/2002
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2005 - 08/2002
2GlucuronidesIBA
04/2005 - 09/2004
2CytokinesIBA
03/2004 - 08/2002
2EnzymesIBA
01/2003 - 07/2002
1A-Form DNA (A-DNA)IBA
07/2012
1Dietary FiberFDA Link
11/2011
1MutagensIBA
11/2011
1aleuroneIBA
11/2011
1ProstaglandinsIBA
06/2009
1SalicylatesIBA
06/2009
1rofecoxib (Vioxx)FDA Link
06/2009
1Celecoxib (Celebrex)FDA Link
06/2009
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
06/2009
1Diclofenac (SR 38)FDA LinkGeneric
06/2009
1Ibuprofen (Motrin)FDA LinkGeneric
06/2009
1Hydroxyindoleacetic AcidIBA
03/2006
1Hematoxylin (Haematoxylon)IBA
03/2006
1Eosine Yellowish-(YS) (Eosin)IBA
03/2006
1Biomarkers (Surrogate Marker)IBA
03/2006
1AlbuminsIBA
08/2005
1bisbenzimide ethoxide trihydrochloride (Hoechst 33342)IBA
08/2005
1Evans Blue (Blue, Evans)FDA Link
08/2005
1Type I Tumor Necrosis Factor ReceptorsIBA
08/2005
1Interferon-gamma (Interferon, gamma)IBA
03/2004
1Starch (Cornstarch)IBA
06/2003
1CarcinogensIBA
06/2003
1Polysaccharides (Glycans)IBA
06/2003
1Proteins (Proteins, Gene)FDA Link
11/2002
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2002
1Immunologic Factors (Immunomodulators)IBA
08/2002
1Drug CombinationsIBA
08/2002
1Biological ProductsIBA
08/2002
1Complementary DNA (cDNA)IBA
07/2002
1dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA
07/2002
1Uridine Diphosphate (UDP)IBA
02/2002
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
02/2002
1Hypnotics and Sedatives (Sedatives)IBA
01/2002

Therapy/Procedure

2Therapeutics
06/2009 - 08/2002
2Drug Therapy (Chemotherapy)
06/2003 - 09/2002
1Intravenous Infusions
08/2002